Posted by hyperfocus on July 10, 2011, at 21:45:08
In reply to Atypical depression - medication no longer helping, posted by policebox on June 27, 2011, at 18:43:15
If you responded partially to Wellbutrin then you should have tried meds with a strong NE effect like Effexor or Pristiq or Cymbalta or Remeron, or TCAs like amitriptyline or desipramine. You could also try combinations of these drugs like Effexor + Wellbutrin. MAOIs are sort of the nuclear option - they tend to work but the side-effects are serious. But if you want to stick with the Parnate you should give it at least 4 weeks. I think the fact that you responded to it for the first week is very encouraging. Nardil also seems to have this acute positive effect for the first few days, which then diminshes, until the true AD theraputic response appears weeks later. I know it's tough to stick it out for a couple of weeks on a med you're not sure is gonna work, but you can get through it. If you've waited a lot of years to find something that can really help, like most of us, then another couple of weeks won't be that bad. If it doesn't work you could try Nardil which could help a lot with the social anxiety, or step back from the MAOI plate and try some of the NE-meds.
C-PTSD: social phobia, major depression, dissociation
Currently on 300mg amitriptyline, 50 mg sulpiride: single dose at night
Also: Allegra 12-hr, 1000mg Vitamin C, multivitamin.
Improving.
poster:hyperfocus
thread:989596
URL: http://www.dr-bob.org/babble/20110630/msgs/990726.html