Posted by bleauberry on July 10, 2011, at 20:01:50
In reply to Feeling terrible on citalopram - need advice., posted by andy013 on July 8, 2011, at 22:19:09
time to say good bye to citalopram and hello to something else in replacement. Whatever the cause of the depression, right now you just need some mood assistance.
It's weird and I cannot explain it. But when a med does something good, and then is stopped and restarted, for some reason it feels like a different med the second time, and sometimes a bad one. Side effects that weren't there the first time are there the second time. An antidepressant effect the first time is a pro-depressant effect the second time.
Some people can stop and restart their med and not have that problem, but others run into bizarre stuff as you have experienced. Me too.
I personally think this has something to do with the almost pure focus on serotonin, with total disregard for the other neurotransmitters. Somehow some way that messes things up in bizarre fashion.
I usually do not favor ssri's monotherapy for that reason. That includes effexor and cymbalta which are predominantly serotonin. I instead feel a lot better about someone's prognosis when there is a balanced approach for both serotonin and norepinephrine. The only things I am aware of that do that pretty good are zoloft+nortriptyline, clomipramine, savella, and sometimes combinations involving prozac and ritalin. And the maois.
Whenever I hear a friend, associate, or whoever who is doing fine on a ssri antidepressant and they are considering stopping it for whatever reason, I usually tell them don't. If it just plain isnt' working or pooped out, that's a different story.
poster:bleauberry
thread:990574
URL: http://www.dr-bob.org/babble/20110630/msgs/990718.html