Posted by europerep on June 22, 2011, at 17:53:40
In reply to Re: can someone explain subnox (sp) to me? » europerep, posted by floatingbridge on June 22, 2011, at 17:06:53
> Thanks europerep. I can remember how to spell your name because you told me what it meant. But yeah, no hiding my spelling deficit :-) I decided not to let it stop me from asking questions (my spell check does not recognize many pharmaceutical words, and, well...). So please enjoy :-)
Don't worry, it's cute ;)..
> This was very helpful. I'm not going that
> route this time around, but am still curious. That kappa receptor action (this one being antagonist) pops up frequently. What that means means nothing to me right now, but I have a
> little time to hit Wikipedia....
Yeah, the kappa antagonism.. they thought kappa AGOnists (not antagnonists) could eventually replace regular opioid painkillers, but in clinical trials it turned out kappa agonists made people dysphoric and eventually depressed.. hence the idea that kappa antagonists might do the opposite, and that appears to be the case. However, buprenorphine also has a metabolite norbuprenorphine that is a delta-receptor agonist, and I personally believe this contributes to the antidepressant effects as well (amitriptyline and nortriptyline also increase delta activity). So, all these things distinguish buprenorphine from the regular opioids, and make it ideal for treatment of depression (only IF one wants go with an opioid of course).I gotta go to bed now, I'll post a little more tomorrow on what I'd suggest you do right now, because to me it seems like your thoughts are a little bit "all over the place", is that right? It would probably be important to make a choice (Parnate, NArdil, etc.) and then pursue that. And when that fails, maybe buprenorphine would be worta try?
Anyhow gotta go,
see you tomorrow!ER
poster:europerep
thread:989031
URL: http://www.dr-bob.org/babble/20110619/msgs/989106.html