Posted by mrtook on April 22, 2011, at 11:21:28
In reply to Re: Deplin at 15mg effective MDD with SSRI's » mrtook, posted by Phillipa on April 20, 2011, at 21:20:36
So I raised lexapro for about 6 months prior to adding deplin.
From what I understand your genes can have
2 copies of the good folic acid metabolizer
2 copies of the bad
or 1 of each
The majority of depressed people will have 1 of each and as a result might experience a smaller and more delayed response from deplin. I believe this is where I fall into although I have never had the genetic workup done.
A minority of people would have two copies of the bad and would see a more immediate and larger effect from the deplin.
From the deplin site they indicated that their research indicated 60% of a depressed population would have one of each and 10% would have both bad copies. Ergo it is not a depression and mental illness smoking gun, but it certainly has a role.
All in all I would recommend most people at least give it a try. It is really a supplement that has some good science behind it. I order it in 90 day 15mg supply and split it and take half every day. This costs around $1 a day.
Best of luck to everyone.