Posted by SusanWhelan on April 15, 2011, at 14:29:22
In reply to Re: Deplin at 15mg effective MDD with SSRI's » SusanWhelan, posted by Phillipa on April 14, 2011, at 21:37:13
There is no risk of cancer associated with Deplin. You may be confused with high doses of unmetabolized folic acid, which is different. Deplin is L-methylfolate, the active form of folate your body makes naturally from folic acid.
Some patients with MTHFR do get a rapid response. Some get response at 7.5mg dose level but research shows (the study you posted) that 15mg dose is far more impactful for many patients. Some patients get a response in 1-2 weeks but others may get a response in 4-6 weeks.
I hope this information helps.