Posted by pedr on April 18, 2011, at 14:27:27
In reply to Re: Nortriptyline vs reboxetine, posted by desolationrower on March 30, 2011, at 12:51:06
> the 'danger' was reboxetine being ineffective. if there is a difference, nortrityline is more effective, and thus less 'dangerous' by that standard. i'm not interested in that article, though.
>FYI That's not quite correct about it being dangerous due to inefficacy according to this https://www.iqwig.de/antidepressants-benefit-of-reboxetine-not-proven.981.en.html
"Alongside the lack of evidence of benefit of reboxetine, there is also proof of harm: patients discontinued treatment more frequently due to adverse side effects, both when compared to placebo and in the comparison with fluoxetine, another antidepressant from the selective serotonin reuptake inhibitor class (SSRI). "
Which was my experience with Reboxetine. Amongst other nasties, shortly after starting Reboxetine I started having constant (and I mean constant), looping, obsessional suicidal thoughts. Amazingly I lasted 2 weeks before calling it a day on Reboxetine - probably because it was one of the few remaining meds I had left to try and was desperate to give it a good try.
And of course, prematurely aborting the transition to a new med means yet another period of awful wash-out, hopes being dashed, new anxieties and so on. Good times, they are not.
BTW I agree with most responders - "if it ain't broke - don't fix it", even if the BMJ says the med is pants.
Treatment Resistant depression, anxiety, OCD: 13 years
IBS-C & GERD: 8 years
Current meds: 90mg Nardil, 300mg Zantac, 20mg Prilosec
poster:pedr
thread:981366
URL: http://www.dr-bob.org/babble/20110418/msgs/983168.html