Posted by desolationrower on March 30, 2011, at 21:15:58
In reply to Re: Alpha-delta sleep and cymbalta? » desolationrower, posted by Christia on March 30, 2011, at 15:48:28
> Thanks for the info! I can't handle Tricyclics well at all, but do you think milnacipran and melatonin would work?
yes, i think that would be close to as good. 5ht2c inhibition is about 2x as effective as 5ht2a inhibition. I would worry that it won't help the fatigue, if it is the sri effect of duloxetine that is causing it. have you ever taken an ssri, and did you have fatigue?
which TCA did you try before? desipramine and notriptyline have less side effects than some of the others.
You could also ask about cyproheptadine. it is an antihistamine as well as 5ht2 antagonist, but it has a reasonably short half-life.
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