Posted by Ron Hill on December 2, 2010, at 5:50:07
In reply to Re: Circadian Clock Linked To Depression Mood » Ron Hill, posted by alchemy on December 1, 2010, at 20:32:02
Alchemy,
I forgot something very important in my prior post to you.
Here is something that has a fairly good chance of helping you, and there are no adverse start-up effects.
Ask you p-doc for a script for 7.5 mg/day of Deplin. Deplin is L-methylfolate, the endogenous form of folate. In other words it is a nutraceutical, but it requires a script. A lot of research these days shows that a deficiency of folate is the cause of depression in many patients.
Further, Lamictal destroys folate. See pages 37, 43, of the Lamictal Prescribing Information document:
http://us.gsk.com/products/assets/us_lamictal.pdf
In order to reduce homocystiene and provide your brain with these nutrients needed to make neurotransmitters and to function in more than 300 biochemical reactions in the brain, add the following to the Deplin:
Sublingual P-5-P (the endogenous form of B-6), and sublingual methylcobalamin (the endogenous form of B-12).
It is absolutely essential that you take the methyl-B12 sublingually (i.e.; hold the tablet under you tongue until it dissolves). When B12 is swallowed down-the-hatch only 1% is absorbed. When it is taken sublingually and, thereby, transferred across the membrane under the tongue directly to the bloodstream, 99% of the B-12 is absorbed.
Taking P-5-P sublingually doesn't taste real good, but you will get used to it. If you do not react well to P-5-P, take about 50 mg/day of B-6 instead.
Here are examples of sublingual methylcobalamin, sublingual P-5-P, and B-6 (if your body disagrees with P-5-P). Please read the product details for each product:
http://www.iherb.com/Jarrow-Formulas-Methyl-B-12-5000-mcg-60-Lozenges/117?at=0
http://www.iherb.com/Source-Naturals-Coenzymated-B-6-25-mg-120-Sublingual-Tablets/1038?at=0
http://www.iherb.com/Carlson-Labs-B-6-50-mg-250-Tablets/10045?at=0
Here is the URL of the Deplin website:
Please, please, please, try this add-on as I have described above.
Lastly, look through the list of stuff I take presented below my med list. I did not come up with this stuff willy-nilly. The things I take are based on research, and anecdotally they all improve my brain chemistry. So, look through my list and pick out the items that your budget allows you to buy, and try them to see if they help. Look up the prices on:
For example, some of the items on my list are very inexpensive, such as 200 mcg/day GTF Chromium and 600 mcg/day Chromium Picolinate, and they can make a huge difference in some patients.
http://www.iherb.com/Nature-s-Way-Chromium-Picolinate-200-mcg-100-Capsules/1879?at=0
http://www.iherb.com/Nature-s-Way-GTF-Chromium-Polynicotinate-100-Capsules/1918?at=0
Magnesium Malate is another example:
http://www.iherb.com/Source-Naturals-Magnesium-Malate-1250-mg-180-Tablets/1444?at=0
D3 can be very effective in the tx of depression and it is very inexpensive:
http://www.iherb.com/Source-Naturals-Vitamin-D-3-2-000-IU-200-Capsules/16666?at=0
As we have talked before, phosphatidylserene (PS) is kind of expensive, but it improves the placidity (pliablity) of the neural cell membranes and, thereby improves the functionality of the receptors. Here is my favorite brand. If I only take 100 mg/day, then the bottle lasts for two months:
http://www.iherb.com/Source-Naturals-Phosphatidyl-Serine-100-100-mg-60-Capsules/1454?at=0
Bottled fish oil is a little expensive, but DHA and EPA are SO GOOD for patients:
http://www.iherb.com/Carlson-Labs-The-Very-Finest-Fish-Oil-Lemon-Flavor-16-8-fl-oz-500-ml/2796?at=0
http://www.iherb.com/Carlson-Labs-The-Very-Finest-Fish-Oil-Orange-Flavor-16-9-fl-oz-500-ml/7799?at=0
If I take as much as was used in the 1999 Andrew Stoll study, I need to drink two bottles per month. So it gets expensive. But, you could take less, and you can eat a lot of canned salmon and/or canned sardines (hey, they aren't bad with a tiny bit of mayo). Here is the Stoll study:
http://archpsyc.highwire.org/cgi/content/full/56/5/407
Ask your p-doc to write a script for a prescription fish oil product like Lovaza. Then your insurance should pay for it.
A bottle of the following CoQ10 lasts me two months:
http://www.iherb.com/Jarrow-Formulas-Co-Q10-200-200-mg-60-Capsules/224?at=0
Each one isn't expensive. But, when they are all added up, it costs quite a bit. But, pick and choose the ones that will fit your budget, and see if it helps. If not, move to the next.
-- Ron
dx: Bipolar II and mild OCPD600 mg/day Trileptal (oxcarbazepine)
200 mg/day Lamictal (lamotrigine)
500 mg/day Keppra (levetiracetam)
90 mg/day Nardil (phenelzine)
12.5 mg every other day Valdoxan (agomelatine)
3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
2.5 mg/day Adderal XR45 ml/day of Carlsons Bottled Fish Oil
100 mg/day phosphatidylserene
1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
2000 IU/day Vitamin D-3
850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
200 mcg/day GTF Chromium
600 mcg/day Chromium Picolinate
200 mg/day Co-Q10
1000 mg/day Cinnamon
480 mg/day Milk Thistle
2 g Vitamin C
Whats next to add?:
NAC, + 8 to 10 glasses of water, + Acetyl-L-Carnitine, + Alpha-Lipoic Acid
poster:Ron Hill
thread:970722
URL: http://www.dr-bob.org/babble/20101117/msgs/972159.html