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Re: Circadian Clock Linked To Depression Mood alchemy

Posted by Ron Hill on November 30, 2010, at 0:20:40

In reply to Re: Circadian Clock Linked To Depression Mood, posted by alchemy on November 20, 2010, at 15:54:06

> Circadian is definitly linked for a lot of cases. All these damn complex gene expressions and cascades of interactions. And some people think I just need to take B12, etc. :)

Due to medical malpractice, I was turned into an ultra rapid cycler; a 15 day cycle consisting of 6 days of deep depression and 9 days of no depression. The 15 day cycle continued constantly without stopping for 14 years.

Over the years, my p-docs and I tried a ton of different meds to stop the ultra rapid cycling and nothing worked. However, four months ago I started taking Valdoxan (agomelatine) and my ultra rapid cycling immediately stopped, and it has never returned. I am free of depression.

Valdoxan is an M1 and M2 agonist and a 5HT2c antagonist. Valdoxan acts on the SCN (Supra-Chiasmatic Nucleus) and, thereby, influences the circadian rhythms. As an aside, DA and NE are released in the frontal cortex due the antagonist action at 5HT2c.

Valdoxan is not FDA approved in the US, but it is approved in several other countries. It is available on the internet.

Novartis purchased the rights from Servier to market the medication in the US. However, Novartis plans to seek FDA approval no sooner than 2012.

Alchemy, I know that I have told you most of this before, but I wanted to put the information in this thread because it is very relevant to the topic.

Below is an excellent link for Valdoxan. No one will arrest you if you click the doctor option. The doctor site has the best information.

-- Ron

dx: Bipolar II and mild OCPD

600 mg/day Trileptal (oxcarbazepine)
200 mg/day Lamictal (lamotrigine)
500 mg/day Keppra (levetiracetam)
90 mg/day Nardil (phenelzine)
12.5 mg every other day Valdoxan (agomelatine)
3.75 mg/day Deplin (taken with 2500 mcg/day of sublingual methyl B-12, and 12.5mg/day of sublingual P-5-P)
2.5 mg/day Adderal XR

45 ml/day of Carlsons Bottled Fish Oil
100 mg/day phosphatidylserene
1 Centrum Chewable Multi-vitamin/day; Only 100% of all the usual vitamins; NO VANADIUM!!
2000 IU/day Vitamin D-3
850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)
200 mcg/day GTF Chromium
600 mcg/day Chromium Picolinate
200 mg/day Co-Q10
1000 mg/day Cinnamon
480 mg/day Milk Thistle
2 g Vitamin C




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