Posted by linkadge on November 14, 2010, at 14:53:10
In reply to Re: Vilazodone vs Nefazodone - 5-HT receptors, posted by Joe Schmoe on November 14, 2010, at 11:49:14
>"To clarify for those that don't really >understand (as I didn't fully up until just a >few days ago), these 5-HT1A partial agonists >aren't actually enhancing 5-HT1A receptor >activity at all, they're decreasing it by >blocking/competing with serotonin -- a full >agonist --, exclusvely at inhibitory 5-HT1A >somatodendritic autoreceptors.
I don't know how accurate this is. For instance, buspar is a preferential autoreceptor agonist. Buspar has been shown to inhibit serotonin release upon acute administration (not enhance it as this guy suggests it would). However, over the long term, the drug would possibly desensitize the autoreceptor leading to enhanced serotonin release.
However, I think what is happening, is that people are morphing the mechanism of action into producing an effect that they have predetermined is "theraptutic". I might remind people that chronically stressing animals leads to a desensitization of the 5-ht1a autoreceptors. Serotonin can be highly anxiogenic, and I think that "control" of the autoreceptor function is more desirable than enhancing or inhibiting it.
Linkadge
poster:linkadge
thread:970074
URL: http://www.dr-bob.org/babble/20101107/msgs/970212.html