Posted by Brainbeard on October 13, 2010, at 12:59:59
In reply to Re: Advice please re. clomipramine/anafranil » Brainbeard, posted by hopefullynow on October 12, 2010, at 8:03:58
Hi the hi,
I've posted an answer several times, but somehow the posting failed.
Thing is, sedation and somnolence can actually be side-effects of noradrenalin reuptake inhibition. They are well known side-effects of atomoxetine (Strattera), an almost pure NRI. Seroquel is probably so sedating because its metabolite is an NRI. Same goes for Geodon, which can knock you out flat: among the many things it does, is pronounced NRI.
Trembling can be a sign of *increased* muscular tone. My trembling gets much worse when I drink coffee. Adrenalin basically puts you in a 'fight or flight' mode. It increases pulse, yields dry mouth, leads to constipation and urinary retention.. You're not going to take a shite or a pee in the middle of dealing with a hungry lion. All these things are present with clomipramine, and they're all a sign of NRI, although of course the anticholinergic action contributes too.
So your conclusion that there's 'not much norepinephrine going on' seems a tad too fast.
> Hy Brainbeard,
> On paper yes, desmethylclomipramine looks strong, but at higher doses of clomipramine, the sedation and somnolence feel stronger.
> I have used to follow a small test in order to qualify a noradrenergic meds regarding their potency: because i train regularly for over a decade, I know my body and my unmedicated muscular tonus.On clomipramine on any dosage over 50 mg/day, I feel weak, trembling, lazy, so not much norepinephrine going on.Au contraire, modest doses of maprotiline added to clomipramine, reversed the weakness, motivation or drive.The same when I added wellbutrin or high doses remeron to clomi.Sometimes I prefer to let alone the studies and abstracts(which i read regularly) and listen to my body.
> > I haven't seen numbers for maprotiline.
> Me neither.It seems it's too old to present interest :(.
Current meds: clomipramine 225mg, fluvoxamine (Luvox) 50mg
As needed: bethanechol 25-50mg, oxazepam 5-10mg