Posted by linkadge on October 12, 2010, at 14:55:30
In reply to Re: going back to bipolar medications, posted by morgan miller on October 11, 2010, at 21:55:42
>As far as seroquel or any other AP is concerned, >I think there is far more potential for insulin >resistance and other metabolic issues than most >SSRIs.
The atypical with the most pronounced metabolic side effects is olanzapine. There is some evidence that seroquel can have similar effects, but the evidence is much less clear.
For some people, seroquel is a lifesaver. As noted in the studies of seroquel for GAD, seroquel provided relief from core symptoms within one week. This was in contrast to the SSRI arms which needed about 6 weeks for effects to become pronounced.
Metabolic concerns are just one side effect, are are probably minimal with doses below 75mg. All medications have side effects. If paxil makes you an insomniac that just wants to veg out all day, this too will take a metabolic toll.
For me, seroquel (an antipsychotic) produced much less apathy than any SSRI. On paper, this should not happen, but its really an individual balanace of benefits and risks.
I have a suspicion that TCAs like doxapin and amitriptyline probably have a very similar metabolic risk (weight gain, hyperlipidemia, glucose issues) (as most potent 5-ht2c antagonists seem to have), but they have not been studied as closely as the atypicals.
Linkadge
poster:linkadge
thread:965275
URL: http://www.dr-bob.org/babble/20101009/msgs/965544.html