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Re: 50mg clomipramine is a HIGH dose with 60mg Prozac » Brainbeard

Posted by Roslynn on October 5, 2010, at 11:52:38

In reply to 50mg clomipramine is a HIGH dose with 60mg Prozac » Roslynn, posted by Brainbeard on October 5, 2010, at 10:38:29

Brainbeard,

Thank you so much, I didn't realize this. No, my pdoc has not requested blood levels.

The combo was not intentional. My doc put me on clomipramine to try to bridge me over while I stopped Prozac in order to start an MAOI.

The thing is, I felt much better when the clomipramine was added to my cocktail, and I wasn't able to stop the Prozac anyway. So now I am on both those meds and I don't think my doc is thrilled with me. He thinks I'm bipolar and should take less antidepressant meds, not more. Complicated, huh?

Thank you so much for your info. I may ask my doc for 5mg of nortrip, maybe it will help me sleep.

Roslynn
>
> Dudette, if you're on 60mg of Prozac, your clomipramine is boosted like a rocket. Your blood levels of desmethylclomipramine, the metabolite working on noradrenaline and mostly responsible for dry mouth and cognitive blurring, are bound to be very high. Desmethylclomipramine gets eliminated through 2D6 enzymes, and Prozac is a major 2D6 inhibitor. So your dose of clomipramine is in fact a very high one. Did you have your blood levels checked? Your doc oughta check on them with this combo.
>
> With 60mg of Prozac, 5-10mg instead of 25-50 of nortriptyline may already be enough for better sleep, since nortriptyline is also metabolized through 2D6.
>
>

 

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