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Bethanechol for dry mouth and constipation

Posted by Brainbeard on October 5, 2010, at 10:45:39

In reply to Re: Clomipramine's Tail Is Smashing My Little Future » Brainbeard, posted by g_g_g_unit on October 5, 2010, at 0:11:16

Me, a pioneer?! I'm taking a fifty year old drug!! ;)

Yeah, bethanechol, and you may be pleased to hear it, actually works far better for me against constipation than it does for dry mouth. It's superb for constipation. I just wish it would also make me drool, but the effects on dry mouth are subtle rather than dramatic.

Sleep disturbances... Yes, clomipramine inhibits 1A2, the enzyme group that breaks down melatonin, and thereby it could promote sleep. But its SRI can counter deep sleep. Clomipramine is probably too weak a 5HT2A-inhibitor to help out with that. I'm thinking of asking my p-doc to add mirtazapine (Remeron) for better sleep.

Hang in there, brother. This drug is/may be/oughta be/ worth its weight in gold.


Current meds: clomipramine 225mg, fluvoxamine (Luvox) 50mg, amitriptyline 10mg, bethanechol 25-50mg.
PRN: oxazepam 5-10mg


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URL: http://www.dr-bob.org/babble/20100926/msgs/964775.html