Posted by Roslynn on August 29, 2010, at 16:31:29
In reply to Nardil + lithium = serotonin syndrome, posted by SLS on August 29, 2010, at 6:19:45
Scott,
I'm sorry you had to go through this. Are you feeling better? Dumb question, but did you have to go to the ER?
Also, what was your dose of lithium and will you be okay without it?
Roslynn
> I recently had to discontinue lithium after adding Nardil to my treatment regime. It seems that the combination of these two drugs produced a mild to moderate serotonin syndrome. Symptoms included diaphoresis, hyperreflexia, ataxia, and hypertonia (especially of the lower back muscles). In addition, I experienced urinary retention that was non-reactive to bethanechol. All of these things disappeared upon the discontinuation of lithium. My rationale for deciding upon lithium as an offending agent was that the pro-serotonergic properties of lithium (serotonin release) acted synergistically with those of Nardil. I had no such problem with the combination of Parnate and lithium.
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> - Scott
poster:Roslynn
thread:960407
URL: http://www.dr-bob.org/babble/20100829/msgs/960505.html