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Nardil + lithium = serotonin syndrome

Posted by SLS on August 29, 2010, at 6:19:45

I recently had to discontinue lithium after adding Nardil to my treatment regime. It seems that the combination of these two drugs produced a mild to moderate serotonin syndrome. Symptoms included diaphoresis, hyperreflexia, ataxia, and hypertonia (especially of the lower back muscles). In addition, I experienced urinary retention that was non-reactive to bethanechol. All of these things disappeared upon the discontinuation of lithium. My rationale for deciding upon lithium as an offending agent was that the pro-serotonergic properties of lithium (serotonin release) acted synergistically with those of Nardil. I had no such problem with the combination of Parnate and lithium.


- Scott


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