Posted by ed_uk2010 on August 8, 2010, at 17:55:14
In reply to Re: Still feeling like sh*t, posted by Maxime on August 8, 2010, at 17:26:51
> Hum. I never tried a low dose. What would be considered a low dose? Would it be safe to take with Parnate?
Desipramine is probably safer than nortriptyline(to combine with Parnate) because it is very selective for the NE transporter. Nortriptyline is a weak SRI.
Desipramine is not sedating and can be taken in the morning. I just checked the Health Canada database and the following tablet strengths are sold in Canada: 10mg, 25mg, 50mg, 75mg and 100mg. Given your previous reaction, I would suggest that you ask your doctor about the 10mg tablets. After reducing the stopping nortriptyline, you could start with 10mg desipramine in the morning and titrate carefully. Less than 100mg per day is considered to be quite low. Response to TCAs is variable so it can take a few weeks to find the best dose. If you went up to a high dose straight away, you might become agitated or hypomanic again. Hopefully, a low dose might be able to relieve your depression without destabilising your mood or causing weight gain. Desipramine might potentiate the Adderall - a reduced dose would be advisable, at least initially.
poster:ed_uk2010
thread:957487
URL: http://www.dr-bob.org/babble/20100731/msgs/957870.html