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Re: Questions about tricyclics???

Posted by SLS on May 8, 2010, at 20:08:45

In reply to Re: Questions about tricyclics???, posted by SLS on May 8, 2010, at 17:38:39

> > Who says social anxiety is a result of serotonin deficit?
>
> I'm trying to figure out why 5-HT1a receptor knock-out mice demonstrate increased anxiety. My mind is mush. Also, people with SA have reduced numbers of 5-HT1a receptors, particularly in the amygdala as determined by PET scans. Are these receptors normally inhibitory or excitatory? I would guess that they would be inhibitory if they are heteroreceptors.

Ok. This explains it:

http://www.pharmacie.u-psud.fr/modules/resources/download/ufrpharmacie/RECHERCHE/Neuron%20paper%201A.pdf


- Scott


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