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Re: Questions about tricyclics???

Posted by SLS on May 8, 2010, at 17:38:39

In reply to Re: Questions about tricyclics???, posted by linkadge on May 8, 2010, at 15:43:05

> Who says social anxiety is a result of serotonin deficit?

I'm trying to figure out why 5-HT1a receptor knock-out mice demonstrate increased anxiety. My mind is mush. Also, people with SA have reduced numbers of 5-HT1a receptors, particularly in the amygdala as determined by PET scans. Are these receptors normally inhibitory or excitatory? I would guess that they would be inhibitory if they are heteroreceptors.

It is interesting that 5-HT1a receptor partial agonists are proposed as efficacious in treating anxiety disorders.


- Scott


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URL: http://www.dr-bob.org/babble/20100504/msgs/946797.html