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Re: TCA's With Opioid Actions?

Posted by SLS on April 10, 2010, at 12:08:33

In reply to TCA's With Opioid Actions?, posted by bulldog2 on April 10, 2010, at 11:52:22

> I've seen this statement made on more than one occassion in reference to TCAs. Is there any scientific proof that any tca's have any influence on opioid receptors and which tca's would that be true for?

I'll be interested to know more about this, too. I read that some TCAs inhibit activity at kappa opioid receptors. That would make sense, I guess, as stimulation of these receptors can produce dysphoria. Also, kappa antagonists produce behavioral changes in rats that resembled those of TCAs.


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URL: http://www.dr-bob.org/babble/20100406/msgs/942958.html