Posted by ed_uk2010 on March 31, 2010, at 17:55:55
In reply to Atomoxetine(Strattera) versus Reboxetine(Edronax), posted by Helena24 on March 31, 2010, at 9:41:36
What country are you in Helena?
> Hi,
> I suffer from chronic ''atypical'' depression and ADD/lack of motivation/anhedonia and severe chronic dysphroria.
>
> I tried almost any psych med available.
> The lack of motivation/enthusiasm for life is my biggest problem,because the years of my life pass by with me just doing nothing productive or enjoyable all day.
> My life is empty.
> I have to force myself to socialize a few times a year just as I have to force myself to pay my bills or going to the bank.
> All of this ''feels'' the same.
>
> The only med that really ever helped was Ritalin,but I can't get it in my country.
> Desipramin (in low doses and for short time) worked good too,but it's also not available.
> Nortriptylin was good too,but inferior to Desipramin.
> Bupropion gave me memory problems.
>
> I have tried almost drug available of all classes.
>
> Now my doctor prescibed me Strattera,10 mg.
> I tried this med a few years ago in the 40 mg dosage and it made me severe depressed and I had to quit taking it.
> Now I startet with a low dose,but it makes me very dysphoric too.
> Now I found out that Atomoxetine has a second metabolite that works as a partial kapppa opioid agonist.This could partially explain the dysphoria it causes.
> Kappa opioid agonism,as far as I know,lowers dopaminergic function in the nucleus accumbens (reward center).
>
> So my thought is to try Reboxetine,that has a similar mechanism of action,without a known kappa agonism.
> This drug is also not available but I could order it online.
>
> Now my question:
> Is there someone who had tried both these drugs for whatever indication and can tell me if or how they ''feel'' different?
> Does Reboxetine cause less dysphoria?
>
> I know this drug isn't available in the US so I don't expect much response.
>
> I will try Edronax/Reboxetine anyway,because I'm really desperate with having no motivation and doing nothing all day!
>
> Even if you tried only one of those two drugs (or low dose desipramine) please answer and discribe how they felt like to you.
>
> Thank you
poster:ed_uk2010
thread:941507
URL: http://www.dr-bob.org/babble/20100328/msgs/941536.html