Posted by Helena24 on March 31, 2010, at 9:41:36
Hi,
I suffer from chronic ''atypical'' depression and ADD/lack of motivation/anhedonia and severe chronic dysphroria.I tried almost any psych med available.
The lack of motivation/enthusiasm for life is my biggest problem,because the years of my life pass by with me just doing nothing productive or enjoyable all day.
My life is empty.
I have to force myself to socialize a few times a year just as I have to force myself to pay my bills or going to the bank.
All of this ''feels'' the same.The only med that really ever helped was Ritalin,but I can't get it in my country.
Desipramin (in low doses and for short time) worked good too,but it's also not available.
Nortriptylin was good too,but inferior to Desipramin.
Bupropion gave me memory problems.I have tried almost drug available of all classes.
Now my doctor prescibed me Strattera,10 mg.
I tried this med a few years ago in the 40 mg dosage and it made me severe depressed and I had to quit taking it.
Now I startet with a low dose,but it makes me very dysphoric too.
Now I found out that Atomoxetine has a second metabolite that works as a partial kapppa opioid agonist.This could partially explain the dysphoria it causes.
Kappa opioid agonism,as far as I know,lowers dopaminergic function in the nucleus accumbens (reward center).So my thought is to try Reboxetine,that has a similar mechanism of action,without a known kappa agonism.
This drug is also not available but I could order it online.Now my question:
Is there someone who had tried both these drugs for whatever indication and can tell me if or how they ''feel'' different?
Does Reboxetine cause less dysphoria?I know this drug isn't available in the US so I don't expect much response.
I will try Edronax/Reboxetine anyway,because I'm really desperate with having no motivation and doing nothing all day!
Even if you tried only one of those two drugs (or low dose desipramine) please answer and discribe how they felt like to you.
Thank you
poster:Helena24
thread:941507
URL: http://www.dr-bob.org/babble/20100328/msgs/941507.html