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Re: Xanax on private prescription in UK » ed_uk2010

Posted by sukarno on March 18, 2010, at 20:35:43

In reply to Re: Xanax on private prescription in UK » sukarno, posted by ed_uk2010 on March 18, 2010, at 15:00:48

Hi Ed. :-)

When I was on lansoprazole (and separately omeprazole) I experienced a syndrome consisting of mental depression and malaise in the beginning and then progressing several days later into a full-blown dengue-like or severe flu-like illness (arthralgia, myalgia, pyrexia and tachycardia >120bpm which lasted 12 hours).

Two rechallenges brought on a more swift and strong reaction. I suppose this is a type of hypersensitivity reaction. Following a desensitisation protocol to omeprazole in a medical abstract also failed.

I recently had the same reaction to saccharin, although 5 years earlier I had used saccharin on a daily basis without incident. I learned that saccharin and PPIs are both sulfonamides, either in structure or post-metabolism.

There is a new PPI in Japan named tenatoprazole, which is not a substituted benzimidazole. Perhaps it won't produce the same reaction. Are you familiar with that PPI?

Thanks,
sukarno


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URL: http://www.dr-bob.org/babble/20100318/msgs/939998.html