Posted by bleauberry on December 28, 2009, at 18:21:17
In reply to Re: Everything You Ever Wanted To Know About Savella, posted by highhatsize on December 28, 2009, at 12:01:40
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> One poster on this board stated about 18 months ago that he didn't know of anyone whose depression was NOT ameliorated by this drug. It was the side-effects that made people drop it.I would tend to agree with that. Obviously there will be someone who won't be helped by it, but I see that percentage being far lower than any other drugs. This is a good drug and unique in some unexplainable way.
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> My reaction was so immediate and severe that I never had the time to evaluate it.Well, I am surprised this urinary side effect has turned up this often. I thought I was the only one! The studies indicated a small percentage. In the real world it would appear to be a higher percentage.
At pubmed, some hospital that did a clinical study, indicated that the remedy for the urinary symptoms is Flomax. Another poster here about a year ago said Flomax immediately cured the urinary problems he had from REboxetine.
I tried Flomax and yes it worked immediately. The problem was, my blood pressure is alredy very very low, and Flomax lowers blood pressure. So that perfect remedy for me turned out to not be so perfect. But it certainly does work as intended to get the urine flowing again.
I discovered by accident that a small dose of just 25mg every other day of Amisulpride improved the symptoms maybe about 50%. How or why I have not a clue. Amisulpride works on D2/D3 receptors and on 5ht7. Obviously the knowledge we have on Amisulpride is not complete.
My gut feeling is a little bit of Nortriptyline would help too, despite it actions of the supposedly guilty norepinephrine in this scenario. Nortriptyline has other functions that could offset it. I pee easier on Nortriptyline, so it is doing something. ???
SLS has a suggestion for an anticholinergic. The thing is though, savella doesn't really have any appreciable cholinergic effect. That said, I learned a long time ago to forget the theory crap...it doesn't work...an anticholinergic like SLS mentioned could indeed work very well. I would love to see someone try it and see. Maybe it will be me.
poster:bleauberry
thread:931002
URL: http://www.dr-bob.org/babble/20091227/msgs/931315.html