Posted by West on December 24, 2009, at 9:08:18
In reply to Re: Slow Down!, posted by linkadge on December 23, 2009, at 18:25:37
Thanks for this. I did know it was a DRI, the rest is news to me.
> Because ketamine is known to produce psychosis, it is often used as a model for schizophrenia (the NMDA model).
Scientists are continually trying to label drugs which simulate psychotic states and model psychiatric states, especially schizophrenia.
'Most of these models have been rejected since it was assumed that the model should be identical to the prototype, while it is impossible to get in animals a psychopathological picture similar to that of human.' *
> Amphetamines are also known to cause psychosis (when used recreationally), but the two types of psychosis differ in their clinical presentation.
Consistent with much of the anecdotal side effects of both drugs.> The NMDA model of schizophrenia is the basis for testing agents like glycine which act as partial agonists at the NMDA receptor and appear to alleviate many of the symptoms of ketamine / PCP psychosis.
Wow, that interesting, but it also seems very short-sighted, desperate even. I find it difficult to believe in any research hoping to accurately model diseases based on how animals behave when doses of these drugs are pushed to crazy levels.
poster:West
thread:930267
URL: http://www.dr-bob.org/babble/20091217/msgs/930687.html