Posted by hopefullynow on November 24, 2009, at 8:12:21
In reply to Re: Treatment resistant OCD » Phidippus, posted by SLS on November 24, 2009, at 5:16:06
> > >Paroxetine and fluoxetine (and its principal metabolite norfluoxetine) are strong inhibitors of CYP2D6 preventing the breakdown of desmethylclomipramine.
> >
> > Does this hold true for Lexapro? I'd like to augment my Lexapro with Anafranil.
>
> Like I said above, you can use full therapeutic dosages of Anafranil with Celexa and Lexapro. Celexa and Lexapro are not inhibitors of 2D6. However, if you believe that Paxil or Prozac would be more effective, you can still add Anafranil. You would just need to reduce the dosage by 50%.
>
>
> - Scott
Scott,
Thanks a lot for clarifying these OCD/depression combos.I have one question: i'm on Anafranil, working up from 125 to 150 and Prozac 20 mg/day and I begin to have real big problems in the sexual department, increased hunger and muscular weakness which really ruin my lovely workouts.In fact i'm not working out right now, I feel like a jelly.Can I combine wellbutrin SR 300 mg/day with Anafranil 150 + mg, without affecting their metabolism?I'm planning to go as higher as possible with Anafranil (maybe 250 mg), but the lack of sexual interest, the muscular weakness and constant hunger make me to think that wellbutrin would help here without interfering too much with clomipramines anti-OCD properties.To sum, now i'm on:
-Anafranil 150 mg
-Prozac 20 mg
-lithium 400 mg
-Klonopin 2mg at bedtime.
I would like to exchange 20 mg Prozac with 300 mg Wellbutrin and maybe add some Mirapex if Wellbutrin is not enough.
What do you think?All the best
poster:hopefullynow
thread:926438
URL: http://www.dr-bob.org/babble/20091117/msgs/926796.html