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Re: Treatment resistant OCD

Posted by SLS on November 23, 2009, at 7:27:00

In reply to Re: Treatment resistant OCD, posted by hopefullynow on November 23, 2009, at 5:54:43

Neither Celexa nor Lexapro inhibit CYP450 2D6 at all. So, Lexapro might make an ideal drug to combine with full therapeutic dosages of Anafranil. The study I cited used Celexa, but with only 75mg of Anafranil. 250mg should have been the maximum dosage tested.

With Paxil, the dosages of TCA should be reduced by 50%. That would indicate that dosages of Anafranil up to 125mg can be used. Prozac is a less potent 2D6 inhibitor than is Paxil, so the same 50% dosage reduction formula should be safe.

If it were me, I would use the maximum dosages of those SSRIs that have shown efficacy in treating OCD, and gradually titrate the Anafranil afterwards.


- Scott

 

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URL: http://www.dr-bob.org/babble/20091117/msgs/926681.html