Posted by SLS on November 20, 2009, at 19:18:34
In reply to Re: Should I discontinue Adderall as Parnate ')SLS, posted by desolationrower on November 20, 2009, at 17:13:22
> >it facilitates neurotoxicity via the loss of DA uptake sites in the striatum and nucleus accumbens.
> what makes you think loss of DATs is 'neurotoxic' and not the therapeutic normalization?Just some stuff I read. I just wish I could find it again. I guess they were all animal studies. I don't think there was any attempt to simulate the levels used in humans. I hope the authors were wrong.
> i think the oxidative stress just comes from metabolizing DA, so if anything its likely to just be bringing it up to normal levls.
I understand where you are coming from. However, one of the major signs of amphetamine-induced neurotoxicity is the loss of DA uptake sites, at least in the striatum and accumbens. Of course, this is an association and not a demonstration of cause and effect. I don't know which comes first, the reduction in DAT or the neurotoxic process.
No one wants to believe that amphetamine is neurotoxic. I don't. Hopefully, any neurotoxicity that is associated with amphetamine use is small and clinically negligible. On the plus side, it seems that there is a recover process capable of reversing the neurotoxic effects of amphetamines. It is very slow, though.
- Scott
poster:SLS
thread:926000
URL: http://www.dr-bob.org/babble/20091117/msgs/926379.html