Posted by delna on November 15, 2009, at 16:40:41
In reply to Re: Dangerously close to the end of the road. Help » delna, posted by SLS on November 15, 2009, at 16:04:01
> I have never heard of Lamictal preventing an antidepressant from producing a therapeutic effect. Some drugs can produce depression or make depression worse, though. However, I have not seen any reports of that happening with Lamictal. If anything, Lamictal can trigger mania or produce anxiety and insomnia. I guess the caveat with using psychotropic drugs is to expect the unexpected, as there can be such interindividual variability in brain organization. That is almost like saying that anything is possible, but not quite.
Ever since I added the Lamictal I have become the most sedate person around- perhaps lacking a personality as some feel. Also I do not go high at all. Before, even the smallest dose of an ssri (or increase in dose) would make me hypomanic. I realize Lamictal is not blocking the therapeutic effect of effexor- just curbing the benefit of a mild high which I think I desperately need.
> Desipramine is a TCA that is usually activating and alerting, although it can be sedating during the first few days. It is selective for norepinephrine (NE). Protriptyline is touted as being the most activating of the TCAs. I find the drug too anticholinergic. It also made my depression significantly worse. Of course, it works perfectly fine for some people.
>
> Reboxetine (Edronax) is a selective NE reuptake inhibitor. I don't think it has any antihistaminergic properties that would otherwise sedate you. Have you ever tried it?I was planning on adding that to the Effexor instead of the wellbutrin. I need the serotonin element for the OCD but of course I can get that from any SSRI like lexapro which is totally non-sedating (but does not impact my depression at all). Do you feel Edronax is a good AD on it's own or only as effective as wellbutrin (which for me only serves as an add-on).
I was under the impression that Edronax was not as powerful an AD as effexor or maybe that was simply my misconception. What do you feel?
Sorry to be such a bother.Thanks again
Love D
poster:delna
thread:925800
URL: http://www.dr-bob.org/babble/20091107/msgs/925855.html