Posted by SLS on November 15, 2009, at 16:04:01
In reply to Re: Dangerously close to the end of the road. Help » SLS, posted by delna on November 15, 2009, at 15:10:37
I have never heard of Lamictal preventing an antidepressant from producing a therapeutic effect. Some drugs can produce depression or make depression worse, though. However, I have not seen any reports of that happening with Lamictal. If anything, Lamictal can trigger mania or produce anxiety and insomnia. I guess the caveat with using psychotropic drugs is to expect the unexpected, as there can be such interindividual variability in brain organization. That is almost like saying that anything is possible, but not quite.
Desipramine is a TCA that is usually activating and alerting, although it can be sedating during the first few days. It is selective for norepinephrine (NE). Protriptyline is touted as being the most activating of the TCAs. I find the drug too anticholinergic. It also made my depression significantly worse. Of course, it works perfectly fine for some people.
Reboxetine (Edronax) is a selective NE reuptake inhibitor. I don't think it has any antihistaminergic properties that would otherwise sedate you. Have you ever tried it?
- Scott
poster:SLS
thread:925800
URL: http://www.dr-bob.org/babble/20091107/msgs/925853.html