Posted by Phidippus on November 2, 2009, at 20:53:32
In reply to d-amphetamine + caffeine use in OCD - study, posted by g_g_g_unit on November 2, 2009, at 15:12:09
Caffeine-induced inhibition of mEPSC amplitude occurs through postsynaptic block of non-NMDA type ionotropic glutamate receptors. Caffeine thus has both pre and postsynaptic sites of action at excitatory synapses. Caffeine inhibits currents activated by direct application of glutamate to cortical neurons, confirming a postsynaptic site of action.
By blocking glutamate transmission, Caffeine and Dextroamphetamine can help control OCD symptoms. GLutamate is the key neurotransmitter implictaed in OCD and most of the drugs shown efficacious in treating OCD in some way inhibit or modulate glutamate.
Riluzole and Memantine are other NMDA antagonists which are being studied to treat OCD.
P
poster:Phidippus
thread:924126
URL: http://www.dr-bob.org/babble/20091029/msgs/924210.html