Posted by linkadge on October 25, 2009, at 10:22:51
In reply to Re: SSRIs as slow speed cocaine - dose related? » Fred23, posted by sowhysosad on October 25, 2009, at 9:58:09
>Yeah, Prozac was initially redolent of very >mild MDMA for me (a similar dual effect on >serotonin and dopmamine?), and a friend said >Effexor felt exactly like amphetamine including >identical side effects (the norepinephrine >boost perhaps?).
I dunno. I had some very initial euphoriant like effects from certain antidepressants. This only lasted a day or two and was very different from the effect that it had on depression.
Initially, the drug might produce euphoria by inhibiting monoamine reuptake in the neucleus accumbens. The NAA responds more quickly than other brain regions, however, by upregulating monoamine transporters to compensate.
The same thing happens with cocaine.
Linkadge
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URL: http://www.dr-bob.org/babble/20091021/msgs/922369.html