Posted by linkadge on October 24, 2009, at 17:01:50
In reply to Re: SSRIs as slow speed cocaine - dose related?, posted by metafunj on October 24, 2009, at 14:08:32
>Here I've seen reports of high doses of Lexapro >being prescribed, e.g. 30 or 40 mg per day, vs. >the more "normal" dose of 10 mg.
Well, for patients that are resistent to lower doses, higher doses are sometimes helpful. SSRI's primarily act on serotonin. Cocaine inhibits the reuptake of serotonin norepinephrine and dopamine and has effects on monoamine release in the neucleus accumbens.
Occasionally SSRI's can cause mild euphoria on startup. I only had this once, possibly because it caused me sleep deprivation. The other times I took SSRI's I felt worse than before for the first few weeks.
>Would those that have this fatigue be more >energized if they went above some threshold, and >had their brain revved up by *higher* doses of >Lexapro? As opposed to higher doses causing even >more fatigue?
Antidepressants are different from stimulants. Higher doses often don't produce more stimulation, with the exception of perhaps wellbutrin, parnate, and desipramine / nortriptyline.
Individual responces vary though,
Linkadge
poster:linkadge
thread:922238
URL: http://www.dr-bob.org/babble/20091021/msgs/922274.html