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Abilify and heat intolerance/sweating

Posted by efishy on October 14, 2009, at 20:58:39

I am a college student on abilify and i have been having a problem for the last year with heat intolerance and sweating [caused by abilify]. I tried to switch to serdolect half a year ago, but then switched back to abilify because of weight gain.

Now i am considering switching to zeldox, since the side effects of abilify are a big disadvantage. Before i do that i want to share my latest thoughts on the cause of this problem.

My theory is that the heat intolerance is caused by a disruption of the 5-ht1a (serotonin 1a) receptor. Abilify is partial agonist of this receptor.

I found that serotonin 1a, 2a, and 2c affect temperature regulation. However it seems that all 2.gen. AP's affect 2a and 2c. Therefore i thought it might be 1a causing the heat intolerance in abilify.

If this is true then i was thinking maybe a 5-ht1a antagonist might help. The only one i could find was pindolol, and this drug doesn't seem too good either.

I am interested in hearing anyone else's thoughts on this subject.


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poster:efishy thread:920950
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