Psycho-Babble Medication | about biological treatments | Framed
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Re: Switch to Amitriptyline Brainbeard

Posted by Bob on September 27, 2009, at 19:09:03

In reply to Re: Switch to Amitriptyline, posted by Brainbeard on September 27, 2009, at 12:30:12

> > I assume that Amitriptyline is associated with weight gain and lethargy as well as significant sexual side effects, correct?
> Weight gain - yes.
> Lethargy - not necessarily. Sedation is not lethargy. One can become quite tolerant to antihistaminergic sedation.
> Sexual side-effects - less likely with amitriptyline than with clomipramine or imipramine, since amitriptyline's SRI isn't that strong.
> Also, amitriptyline's affinity for 5HT2A-receptors (as an antagonist) is pretty close to its affinity for serotonin receptors, and 5HT2A-antagonism is likely to counter SRI-induced sexual side-effects. (See, table 3).

Thanks for that info. Very informative.




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