Posted by Bob on September 27, 2009, at 19:09:03
In reply to Re: Switch to Amitriptyline, posted by Brainbeard on September 27, 2009, at 12:30:12
> > I assume that Amitriptyline is associated with weight gain and lethargy as well as significant sexual side effects, correct?
>
> Weight gain - yes.
>
> Lethargy - not necessarily. Sedation is not lethargy. One can become quite tolerant to antihistaminergic sedation.
>
> Sexual side-effects - less likely with amitriptyline than with clomipramine or imipramine, since amitriptyline's SRI isn't that strong.
>
> Also, amitriptyline's affinity for 5HT2A-receptors (as an antagonist) is pretty close to its affinity for serotonin receptors, and 5HT2A-antagonism is likely to counter SRI-induced sexual side-effects. (See http://www3.interscience.wiley.com/cgi-bin/fulltext/121665024/HTMLSTART?CRETRY=1&SRETRY=0, table 3).
>
>Thanks for that info. Very informative.
poster:Bob
thread:913623
URL: http://www.dr-bob.org/babble/20090921/msgs/918752.html