Psycho-Babble Medication | about biological treatments | Framed
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Re: Switch to Amitriptyline

Posted by SLS on August 23, 2009, at 18:07:30

In reply to Re: Switch to Amitriptyline, posted by linkadge on August 23, 2009, at 16:47:49

> I figured that amitriptyline and doxapin would probably be very similar in terms of effect and side effect profile. Doxapin is genotoxic, wherase amitriptyline appears not to be?

That's what has been reported.

I think you made the right choice. Again, I would just caution you that an elevated heart rate is the nature of the beast. I don't think it should be a deal-breaker, especially in light that it does moderate over time. My heart rate on nortriptyline is 80bpm at the moment. You should realize that with its more potent anticholinergic properties, you might see your HR go over 100bpm at times for the first few weeks. When I first tried a combination of Parnate and desipramine, I was at 120bpm for awhile. I didn't give a damn, though. I had too much to gain. The combination worked extremely well until my doctor had me discontinue the treatment, thinking that "mission accomplished". The same treatment never worked well for me again.

Amitriptyline might be soporific for the first few days, but that should subside.

- Scott




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