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Re: Consensus on Mirapex (pramipexole)-Bob Brain Damage

Posted by SLS on August 20, 2009, at 5:51:13

In reply to Re: Consensus on Mirapex (pramipexole)-Bob, posted by Brain Damage on August 20, 2009, at 2:50:16

> I doubt Piribedil would be any less likely to stop working than Miripex
> However it is more stimulating & less likely to cause sleepines.
> I'm afraid Piribedil is not available in the US or the UK :(

Formily known as ET-495, piribedil (Trivastal) was used investigationally in the 1980s in the US. My doctor at the time would have liked to combine it with Parnate. Piribedil stimulates D2 receptors and blocks D3 receptors. That there are D3 autorecptors is a significant finding. Blocking these receptors likely produces an increase in the synthesis and release of dopamine. Unlike piribedil, pramipexole (Mirapex) and ropinerole (Requip) stimulate D3 receptors. What I am unsure of is where these neurons are located. My guess is that they are present in the limbic system in areas like the nucleus accumbens (reward, motivation). D2 autoreceptor stimulation is the probably the cause of sleep attacks with piribedil, pramipexole, and ropinerole.

- Scott




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