Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Consensus on Mirapex (pramipexole)-Bob Brain Damage

Posted by SLS on August 20, 2009, at 5:51:13

In reply to Re: Consensus on Mirapex (pramipexole)-Bob, posted by Brain Damage on August 20, 2009, at 2:50:16

> I doubt Piribedil would be any less likely to stop working than Miripex
>
> However it is more stimulating & less likely to cause sleepines.
> I'm afraid Piribedil is not available in the US or the UK :(

Formily known as ET-495, piribedil (Trivastal) was used investigationally in the 1980s in the US. My doctor at the time would have liked to combine it with Parnate. Piribedil stimulates D2 receptors and blocks D3 receptors. That there are D3 autorecptors is a significant finding. Blocking these receptors likely produces an increase in the synthesis and release of dopamine. Unlike piribedil, pramipexole (Mirapex) and ropinerole (Requip) stimulate D3 receptors. What I am unsure of is where these neurons are located. My guess is that they are present in the limbic system in areas like the nucleus accumbens (reward, motivation). D2 autoreceptor stimulation is the probably the cause of sleep attacks with piribedil, pramipexole, and ropinerole.


- Scott

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:912879
URL: http://www.dr-bob.org/babble/20090818/msgs/913097.html