Posted by SLS on July 25, 2009, at 8:17:46
In reply to Re: Extreme internal restlessness/agitation!!!! HE » jerrypharmstudent, posted by linkadge on July 25, 2009, at 7:22:45
> A number of doctors think that zyprexa (and other atypicals) augments SSRI's owing to its 5-ht2a/c receptor blockade and possibly its muscarinic receptor antagonism. Most TCA's share these effects (less so with imipramine and desipramine though).
Your rationale for substituting Zyprexa with nortriptyline makes a lot of sense.
Interestingly, I gleaned a brief antidepressant response to all of the atypicals I tried except for Seroquel. Seroquel is the one drug in this class that does not antagonize 5-HT2c receptors.
- Scott
poster:SLS
thread:908370
URL: http://www.dr-bob.org/babble/20090721/msgs/908466.html