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Re: Venlafaxine and Trazodone a good combo

Posted by SLS on July 18, 2009, at 6:14:00

In reply to Venlafaxine and Trazodone a good combo, posted by ben on July 18, 2009, at 4:50:58

> Does anyone has experience in augmenting Venlafaxine with Trazodone. Not because of sleep problems- because of lack of efficacy of Venlafaxine.

I don't remember seeing anyone use trazodone to augment other antidepressants in the hopes of producing a therapeutic synergy.

Trazodone is primarily an antagonist of 5-HT1a and 5-HT2a serotonin receptors (although it does inhibit its reuptake to an extent.

It might work. Perhaps your doctor has had a good experience with the combination. Other drugs to combine with Effexor include Wellbutrin, nortriptyline, and Remeron.

I tried high dosages of trazodone when it was first marketed in 1982. I didn't like the way I felt on it, and I did not experience an antidepressant effect. I have not tried nefazodone, though.


- Scott

 

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