Posted by linkadge on July 1, 2009, at 20:19:35
In reply to Re: zinc inhibits TREK-1, posted by mogger on July 1, 2009, at 18:29:20
No it doesn't list the dose. Compared to other agents zinc is less potent. The SSRI antidepressants fluoxetine, paroxetine and sertraline also inhibit TREK-1 channels in the order of potence sertraline > paroxetine > fluoxetine.
Lamotrigine is a TREK-1 channel inhibtor which may account for its antidepressant like effect.
Perhaps newer agents with high selectivity and potency for this target will prove to be effective antdepressant agents.
Linkadge
poster:linkadge
thread:904249
URL: http://www.dr-bob.org/babble/20090630/msgs/904291.html