Posted by morganpmiller on June 30, 2009, at 3:36:39
In reply to Re: A similar study, posted by linkadge on June 29, 2009, at 7:43:12
>Do you know about the study on Zoloft giving >evidence for it's use in treating melanoma?
>It is an investigational treatment. Just like citalopram was an investigational (failed) tretment for autism.
The antidepressant sertraline downregulates Akt and has activity against melanoma cells
Kalpana K. Reddy 1 , Benjamin Lefkove 1 , Lan Bo Chen 2 , Baskaran Govindarajan 1 , Arkaitz Carracedo 3 , Guillermo Velasco 3 , Carol O. Carrillo 1 , Sulochana S. Bhandarkar 1 , Michael J. Owens 4 , Fatima Mechta-Grigoriou 5 and Jack L. Arbiser 1*
1 Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
2 Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
3 Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
4 Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
5 Unit of Gene Expression and Diseases, CNRS URA 1644, Pasteur Institute, Paris, France
*Address correspondence to Jack L. Arbiser, e-mail: jarbise@emory.edu
Copyright Journal compilation © 2008 Blackwell Munksgaard
KEYWORDS
sertraline melanoma AKT SSRI signal transduction reactive oxygen
ABSTRACTMelanoma is a common malignancy which is poorly responsive to chemotherapy and radiation. One of the major reasons melanoma responds poorly to these modalities is constitutive expression of Akt, which protects against apoptosis. The antidepressant sertraline was found to be a potent cytotoxic agent against A375 human melanoma. To determine the mechanism by which sertraline kills melanoma cells, Western blot analysis of signaling molecules, including phosphorylated Akt, caspase 9 and phospho-p70 S6 kinase was performed. Finally, the effects of sertraline on A375 xenografts in mice were assessed. Sertaline potently inhibited the phosphorylation of Akt, and caused cell death through induction of endoplasmic reticulum in vitro. Sertraline monotherapy demonstrated activity against A375 xenografts in vivo. Akt is a major cause of resistance of melanoma to current therapy. Antidepressants are commonly used to prevent interferon-induced depression. Use of antidepressants that decrease Akt may improve the efficacy of interferon and other therapies against melanoma. Further studies are needed to elucidate whether sertraline acts as an Akt inhibitor in melanoma.
I don't think you can compare this to celexa and autism treatment
poster:morganpmiller
thread:903591
URL: http://www.dr-bob.org/babble/20090620/msgs/903902.html