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Chemist question....Larry?

Posted by bleauberry on May 31, 2009, at 17:00:58

So, I would like to try a restart of Milnacipran. I prefer the European ones I have because they are powder I can empty from colored capsules. The USA version, Savella, is in tab form with FDA red, aluminum, and stuff that is not cool with me.

Description of Savella, Milnacipran:

"Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: (±)-[1R(S),2S(R)]-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride.

Milnacipran hydrochloride is a white to off-white crystalline powder with a melting point of 179°C. It is freely soluble in water, methanol, ethanol, chloroform, and methylene chloride and sparingly soluble in diethyl ether. It has an empirical formula of C15H23ClN2O and a molecular weight of 282.8 g/mol."

My question is:
Can I mix the contents of a 50mg capsule in a measured glass of water and drink custom sized doses? That would be a whole lot more accurate than trying to divide up little piles and reload them in empty capsules, which is what I did previously.

My intended starting dose will be extremely low. Last time I only did 6.25mg twice a day and got some fairly impressive results at just 2 weeks. Not bad for someone who failed ECT. Good drug. Difficuty going pee was bad and is what had me stop the med. This time I want to start even lower, give it a month or two, and hopefully allow the adrenergic receptors in the bladder department to adapt, and then go up in dose...if I need to. If the results are anything like last time, I will stay at the miniscule dose and be plenty happy with it.

My whole plan depends on getting small doses as accurately as possible, so I am hoping I can mix into water or juice or something readily available to a non-chemist.

Water? Juice? Other? What's best to mix it in? How long does one think it would stay good in the fridge?

Thank you very much!


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poster:bleauberry thread:898650
URL: http://www.dr-bob.org/babble/20090531/msgs/898650.html