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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by bleauberry on May 31, 2009, at 17:00:58
So, I would like to try a restart of Milnacipran. I prefer the European ones I have because they are powder I can empty from colored capsules. The USA version, Savella, is in tab form with FDA red, aluminum, and stuff that is not cool with me.
Description of Savella, Milnacipran:
"Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: (±)-[1R(S),2S(R)]-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride.
Milnacipran hydrochloride is a white to off-white crystalline powder with a melting point of 179°C. It is freely soluble in water, methanol, ethanol, chloroform, and methylene chloride and sparingly soluble in diethyl ether. It has an empirical formula of C15H23ClN2O and a molecular weight of 282.8 g/mol."
My question is:
Can I mix the contents of a 50mg capsule in a measured glass of water and drink custom sized doses? That would be a whole lot more accurate than trying to divide up little piles and reload them in empty capsules, which is what I did previously.My intended starting dose will be extremely low. Last time I only did 6.25mg twice a day and got some fairly impressive results at just 2 weeks. Not bad for someone who failed ECT. Good drug. Difficuty going pee was bad and is what had me stop the med. This time I want to start even lower, give it a month or two, and hopefully allow the adrenergic receptors in the bladder department to adapt, and then go up in dose...if I need to. If the results are anything like last time, I will stay at the miniscule dose and be plenty happy with it.
My whole plan depends on getting small doses as accurately as possible, so I am hoping I can mix into water or juice or something readily available to a non-chemist.
Water? Juice? Other? What's best to mix it in? How long does one think it would stay good in the fridge?
Thank you very much!
Posted by Larry Hoover on May 31, 2009, at 18:18:06
In reply to Chemist question....Larry?, posted by bleauberry on May 31, 2009, at 17:00:58
I can't see any obvious points of degradation or reactivity in the molecular structure, and that's consistent with the fact that it passes through the gut unchanged, is largely unaffected by liver enzymes, and is excreted unchanged, or as a conjugated glucoronide. Only small percentages of metabolites are detected. So, as stomach acid doesn't break it down, and liver enzymes hardly affect it, I think it would be safe to conclude that water won't hurt it.
As it is freely soluble in water, I'd go with that. I can't foresee any problems with stability if kept in the fridge. If the taste is a problem, then I might consider juice or flavorings or such.
I hope this works for you.
Lar
Posted by bulldog2 on June 1, 2009, at 14:22:41
In reply to Chemist question....Larry?, posted by bleauberry on May 31, 2009, at 17:00:58
> So, I would like to try a restart of Milnacipran. I prefer the European ones I have because they are powder I can empty from colored capsules. The USA version, Savella, is in tab form with FDA red, aluminum, and stuff that is not cool with me.
>
> Description of Savella, Milnacipran:
>
> "Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor; it inhibits norepinephrine uptake with greater potency than serotonin. It is a racemic mixture with the chemical name: (±)-[1R(S),2S(R)]-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride.
>
> Milnacipran hydrochloride is a white to off-white crystalline powder with a melting point of 179°C. It is freely soluble in water, methanol, ethanol, chloroform, and methylene chloride and sparingly soluble in diethyl ether. It has an empirical formula of C15H23ClN2O and a molecular weight of 282.8 g/mol."
>
> My question is:
> Can I mix the contents of a 50mg capsule in a measured glass of water and drink custom sized doses? That would be a whole lot more accurate than trying to divide up little piles and reload them in empty capsules, which is what I did previously.
>
> My intended starting dose will be extremely low. Last time I only did 6.25mg twice a day and got some fairly impressive results at just 2 weeks. Not bad for someone who failed ECT. Good drug. Difficuty going pee was bad and is what had me stop the med. This time I want to start even lower, give it a month or two, and hopefully allow the adrenergic receptors in the bladder department to adapt, and then go up in dose...if I need to. If the results are anything like last time, I will stay at the miniscule dose and be plenty happy with it.
>
> My whole plan depends on getting small doses as accurately as possible, so I am hoping I can mix into water or juice or something readily available to a non-chemist.
>
> Water? Juice? Other? What's best to mix it in? How long does one think it would stay good in the fridge?
>
> Thank you very much!
>drugs of this class my neutralize the pee effect of minalciprin
Posted by bleauberry on June 1, 2009, at 16:25:35
In reply to Re: Chemist question....Larry? » bleauberry, posted by Larry Hoover on May 31, 2009, at 18:18:06
Larry, thanks for your prompt review! Much appreciated.
Posted by bleauberry on June 1, 2009, at 16:42:18
In reply to Re: Chemist question....Larry?, posted by bulldog2 on June 1, 2009, at 14:22:41
>
> drugs of this class my neutralize the pee effect of minalciprin
>
> http://www.drugs.com/pro/hytrin.htmlI have tried Flomax, and it does indeed work quite well. The side effects were horrendous however. Massive unimaginable fatigue and deep dark gloomy depression, hitting within hours of the first small dose. Unfortunately the affinity for urinary alpha-1 adrenergic receptors is not completely exclusive to just urinary receptors. While investigating what other patients had to say about these meds, it was not overly frequent, but not uncommon either, to see things like, "depression", "apathy", "fatigue", "impotence" as debiliatating side effects of Flomax and its cousins.
This is the end of the thread.
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