Posted by tonyz on May 10, 2009, at 21:30:45
In reply to Re: Opinions on Supplements with SAM-e » tonyz, posted by raisinb on May 6, 2009, at 21:06:43
Appreciate all the comments. Doc has suggested SAM-e with an 800mg daily dose with 2 400mg daily doses spaced about 4 hours apart with the last one around 12pm. Actually this was my suggestion and doc agreed. Also added a small dosage of remeron 7.5mg, and have been taking 10mg of valium which I am slowly trying to taper.
The SAMe has worked for me in the past. It is really hard to gauge the level of effectiveness. Sometimes I think it was as good as Nortriptyline at very high dosages. The insomnia is a big issue. The Nortriptyline just trashes my body -- difficult to explain w/o going into a lot of details but my body is so much better w/o Nortriptyline. I think SSRIs would be too stimulating they have never worked for me in the past, but then I have never been on any of them for that long. My depression has a lot of anxiety so even with the sedating antidepressants I would require some adjunct to help me get some sleep. Ambien, Lunesta, Sonata have not proven to be helpful.
The small amount of remeron seems to be doing something but it is hard to tell. My doc is not an expert on using SAM-e. In general, I think it is hard to find one that is. I would like to add some cofactors like B-vitamins and folate or trimethylglycine, but I don't feel comfortable making this decision on my own. I understand to a limited extent the methylation process and the byproduct homocysteine which is produced which is not a good thing. The co-factors can help recycle this which allows the body to produce more SAMe on its own. At least that is my understanding.
I looked at the alternative board and I didn't come across anything on SAMe. Maybe I missed something.
Anyway we'll see how it goes. Best of luck to all of us. This sucks but we'll manage to get through it.
poster:tonyz
thread:893719
URL: http://www.dr-bob.org/babble/20090505/msgs/895103.html