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Re: Dopamine depletion: A myth? » SLS

Posted by garnet71 on April 11, 2009, at 10:31:33

In reply to Dopamine depletion: A myth?, posted by SLS on April 9, 2009, at 8:10:25

well here's some links to some full text research, though older, the links are embedded in text on the site. I don't know if its the right stuff you are looking for or if it would help answer your question, because i generally don't read this technical stuff or need a translator. (I have no clue)

http://www.nature.com/npp/journal/v20/n5/full/1395291a.html


Functional interactions between central serotonin (5-HT) and dopamine (DA) systems have been well documented. Electrophysiological, biochemical, and behavioral evidence suggests that the ascending serotonergic pathways from the medial and dorsal raphe modulate or control the function of the mesolimbic and mesostriatal dopamine systems (Joyce 1993; Zazpe et al. 1994; Kapur and Remington 1996). The modulating effect of serotonin on striatal dopamine release is, however, controversial. For example, there is evidence that serotonin may inhibit (de Belleroche and Bradford 1980; Ennis et al. 1981; Westfall and Tittermary 1982; Blandina et al. 1988) as well as stimulate DA release in the striatum (Benloucif et al. 1993; West and Galloway 1996; De Deurwaerdere et al. 1997). Similarly, local application of 5-HT or 5-HT agonists have been shown to reduce (de Belleroche and Gardiner 1982) and facilitate dopamine efflux in the nucleus accumbens (Guan and McBride 1989; Parson and Justice 1993). In respect to the 5-HT2 receptor agonist properties of psilocybin, it is of particular note that 3,4-methylenedioxymethamphetamine (MDMA), a potent 5-HT releasing agent, has been shown to increase impulse-mediated striatal dopamine release through 5-HT2 receptor activation (Schmidt et al. 1992; Palfreyman et al. 1993; Schmidt et al. 1994; Yamamoto et al. 1995; Gudelsky and Nash 1996). Thus, 5-HT2A receptors located on dopaminergic and/or GABAergic neurons within the striatum and nucleus accumbens might provide an anatomical substrate for a serotonin-mediated psilocybin-induced dopamine release (Palacios et al. 1991).

 

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poster:garnet71 thread:889611
URL: http://www.dr-bob.org/babble/20090408/msgs/889947.html