Posted by desolationrower on April 9, 2009, at 14:33:04
In reply to Re: Dopamine depletion: A myth?, posted by Phillipa on April 9, 2009, at 12:11:50
well, this seems like a theory thought up by people who think they can understand the brain (i don't mean, 'idiots', i mean, overconfident and not realizing the complexity). i mean it combines a goofy 'theory' with the idea that you can 'feel' the effect of a neurotransmitter. not that the idea of 'depletion' is completely crazy, theres some evidence that NA can be depleted in certain circumstances naturally, and i think mdma use depletes serotonin, but where does this theory come from? i haven't seen anything that says for instance that tyrosine hydroxylase is downregulated by ssris. if there is something going on it is probably a complex web keeping the equilibrium off like hypcortisolemia, downregulated 5ht2, or something like that. but looking at known effects of ssris seems like the place to start, not brotelligence about dopamine.
-d/r
poster:desolationrower
thread:889611
URL: http://www.dr-bob.org/babble/20090408/msgs/889665.html