Posted by SLS on March 7, 2009, at 6:12:55
In reply to Re: Seroquel XR 300mg, posted by Relapse on March 6, 2009, at 22:57:12
> My doc. wants me to take it to help me sleep. He explained to me that I could take up to 400mg at night.
> I see a lot of folks here taking far less than that for sleep (25mg-50mg). Really 200mg now seems to do very little in the way of making me tired now (tolerance?).
It probably has more to do with a build up of the major metabolite of Seroquel, which is a potent NE reuptake inhibitor. This can be very alerting and cancels out the sedative effect. I would try 50mg to see what happens. It might take a few days for the metabolite to be eliminated from the body, so don't judge your reaction to the lower dose on the first night.
Good luck.
- Scott
poster:SLS
thread:884034
URL: http://www.dr-bob.org/babble/20090304/msgs/884220.html