Posted by Pete1968 on January 16, 2009, at 12:05:08
In reply to Re: Duloxetine ineffective?, posted by desolationrower on January 16, 2009, at 1:24:31
Thank you all for replying, I am grateful for your views. Reggie BoStar, thank you for your input, I had never heard of the possibility combining the two SNRI meds before, I had always thought that wasnt really advisable, but then I am new to all this. Wouldnt combining Duloxetine and Venlafaxine run a risk of serotonin syndrome? I read up on Pristiq and it sees that it is essentially Venlafaxines metabolite, although I did benefit to a degree from Venlafaxine 150mg I didnt achieve full remission of symptom and decided to try Duloxetine 60mg in the hope that this would prove more potent, in the last 4 weeks I have actually felt worse than when I was taking Venlafaxine, I suppose I could always up the dose but I am a little concerned about increasing anxiety due to higher reuptake inhibition of Noradrenaline.
Its not that suffered 'poop out' with either drug, its just that I didnt feel like my MDD was sufficiently improved on the Venlafaxine, I have had experience with SSRIs including Escitalopram in the past (admittely not while severely depressed) and found them to improve mood more than SNRIs. However it was living with the constant diahorreah that made me quit in the end.
I take your point Desolationrower about treating the gastro side effects of SSRI use, it would be better to be less depressed and deal with it than the other way around.
And Linkadge, I am interested to know that the SNRI vs SSRI thing is disputed.
I can only assume from my personal experience that the serotonin blocking capabilities of SSRI's is more potent than SNRI's as SSRIS cause a notable increase in gastric peristalsis in me whereas the SNRIs do not. Apparently Serotonin is responsible for this.
I was wondering if anyone else has found Duloxetine (Cymbalta) to be ineffective in relieving symptoms of depression?
poster:Pete1968
thread:874178
URL: http://www.dr-bob.org/babble/20090104/msgs/874329.html