Posted by ParnateStarted2008 on January 3, 2009, at 22:20:25
In reply to What was or is your PARNATE experience?, posted by JadeKelly on January 2, 2009, at 18:52:13
I switched from Nardil to Parnate about 5 month ago. I switched over night from 90mgsNardil to 40mgParnate. I have augmented up to 70mgs now. I have Social Phobia which leads to depression and agoraphobia.
Each 10 mg dose increase gives me a stimulating, euphoric buzz that lasts 1-3 days then stops. I ve been reading here that higher doses of Parnate help people with anxiety (like 80mg/day +)? So maybe I should beging thinking about going higher.
I find Parnate has minimal side effects, insomnia being the only really hard one. All other SE's are tolerable ie. rapid heart beat after dosing for about an hour, increase libito, little bit of jaw clenching, over stimulated emotions across the entire spectrum.Here is a weid thing that happens to me while on Parnate/Nardil... any input would be nice or if anyone has similar experiences.
NArdil&Parnate: after 12 hours of my last dose I become happier, easy going, have a big smile on my face, enjoy talking to people and joking around and has a great antianxiety effect. The happy feeling is what kills anxiety and from my experience is how ssri's made me feel when they were working. Paxil,Celexa,Zoloft all working purely on serotonin making me happy with euphoria making previous anxiety provoking situations much easier to handle because im not scared in the situation, the happiness of the pill keeps me happy allowing me to just forget about being terrified and do the task because im so damn happy. Well that was a long time ago when ssri's worked. Effexor shared this same happy quality except also has the Dopamine and NE working so that made me task oriented aswell as being happy (efexor quit on me after a month). This happy serotonin feeling gets me quite euphoric and I can easily be riding a thin line close to hypomania. In this state I was productive and mentally satisfied. I am now on the never ending quest to get back there.
For some reason 12-15 hours after my last dose(Parnate/Nardil) I feel the happy feeling and Its just wonderful to say the least. I can last in this state for 2 days if I dont dose. After 2 days withdrawl becomes evident so I have to take my Parnate/Nardil again. When I do, the happy feeling dissapears and it seems as tho the med isnt working. I cant explain why this happens but it does. I have a funny feeling that after 12 hours the Epineph/Norepineph/DA effect dissapears but the serotonin effect stays for a couple days. Its like as if when all 4 major neurotransmitters are in balance in the synaptic gap they cancel each other out and I dont feel very well. Its like after about 12 hours or so all neurotransmitters are down regulated by having less of the medication to keep their concentrations high But it seems like serotonin does not get down regulated or loose its effect for about 2 days allowing me to feel solely its effect since the other neuros are long gone deminished.
I have no clue if that is what happens, but it seems to be the simplest explenation I can come up with... this just help to explain how I feel.
So how can I remain in the "good state"?
poster:ParnateStarted2008
thread:871986
URL: http://www.dr-bob.org/babble/20081223/msgs/872185.html