Posted by bulldog2 on January 3, 2009, at 12:53:21
In reply to Re: What was or is your PARNATE experience? » shasling, posted by JadeKelly on January 3, 2009, at 11:59:20
> Hi guys,
>
> My first week on Parnate was uneventful. I started at 30mg in morns. 2nd week was incredible, no depression AT ALL, extra good mood (quite amazing), found out thats a feeling that follows most dose increases for a few days. Have had transient sleep problems, sometimes insomnia, sometimes fall asleep early and sleep late. For a little while, I had late day fatigue but if I faught it, it would subside in an hour or less. Most people lose wieght in the first 3-4 weeks or so, unless you remember to eat 3 meals. If you want to you could easily lose weight on Parnate.
>
> My 11th day woke with bad headache and high BP, ended up just waiting it out at Hosp. Still don't know what caused it, and haven't had any high BP since. I did get smart and get script from PDoc, an antidote called Nifedipine. I keep it in my purse and at home. Havent needed it but nice to know its there. Low BP was annoying for me in beginning. I'd have to stand up slowly or I'd get dizzy and have to lay down. That mostly passed several weeks in. Stayed at 30mg for 6 weeks, I think cause Doc forgot me! I called and asked to go to 40mg, I got 3-4 days of bliss, week 1/2 later, went to 50mg, 3-4 days of bliss. At 40mg I started dosing twice a day, 8am, then noon. Probably could have waited till 1 or 2. I feel good stimulation a little while after dosing.
>
> Late December, I added 5mg ritalin (DON'T DO THIS EXCEPT UNDER DOCS CARE). My Depression came with an unbelievable lethargy, so even with stim from Parnate, I NEEDED a boost for holidays. First day didn't feel it at all. 2nd day on Parnate and ritalin, I went into 10 day remission. Not "high" like when dosing, but felt great and like myself again. Unfortunately, 11-12 days later it was gone. I wish I had known this is common. Next, 2 days of emotional extremes. I cried for the first time in YEARS. I was angry and irritable, etc. Some, I, hear, get sensitive in a good way. Not me, so I got some advise (PDOC out of town) and took melatonin-plus, 6mg, and felt calm again. Also great for sleep btw. I have klonopin and I prefer melatonin for sleep. If you wake up during the night, take one at bedtime, and one when you wake up. I've also added lithium, that seems to help even out my mood.
>
> So here it is:
>
> 60mg Parnate
> 5-10mg ritalin
> 450 Lithium ER
> sleep aid
>
> Mood so-so, I will post when full remission happens. It happened for 10 days, so I'm waiting for rest of MAOI to do its job, and hopefully, 100% response as before.
>
> ~Jade
>
> PS-my diagnosis: TR/MDDFrom what's I've read parnate has two fold action. It has the structure of a stimulant and also maoi action. I think the immediate ad response some people get are due to the stimulant response which later disappears. Possibly each dosage increase gives a brief stimulant response. Than hopefully the maoi ad response kicks in.I think ritalin blocks reuptake of ne which makes it safer than other stims which just cause a release of ne.
I have a feeling that the spontaneous hypertensive crisis for some is due to it's two fold action. You're getting an maoi along with stim action which releases ne.The other maois don't have this action so hence have less hypertensive reaction.
poster:bulldog2
thread:871986
URL: http://www.dr-bob.org/babble/20081223/msgs/872095.html